Novel redox clamping agents and uses thereof

Neuartige komplexierende redoxagenzien sowie deren verwendung

Nouveaux agents de fixation d'oxydoreduction et leurs utilisations


Redox clamping agents which maintain cells in a selected redox state are provided. Also provided are methods of using the redox clamping agents to sensitize cells to chemotherapeutic agents such as antineoplastics, to inhibit hyperproliferation of cells and to stabilize the redox state of cells with abnormal fluctuations in their redox state.
L'invention concerne des agents de fixation d'oxydoréduction permettant de maintenir des cellules dans un état d'oxydoréduction donné. Cette invention concerne également des procédés d'utilisation de ces agents de fixation d'oxydoréduction destinés à sensibiliser les cellules à des agents chimiothérapeutiques comme les antinéoplasiques, de manière à inhiber l'hyperprolifération desdites cellules et à stabiliser l'état d'oxydoréduction des cellules dont l'état d'oxydoréduction fluctue de manière anormale.




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Patent Citations (3)

    Publication numberPublication dateAssigneeTitle
    US-5019596-AMay 28, 1991Schering SpaPharmaceutical compositions having therapeutical activity based on mercaptoethansulphonic acid
    WO-9425626-A1November 10, 1994Pacific Northwest Research FoundationDna profiles as an indicator of cellular redox potential and cancer risk
    WO-9611004-A1April 18, 1996Deutsches Krebsforschungszentrum Stiftung des öffentlichen RechtsAgent pour le traitement de lesions malignes et pre-malignes positives de papillomavirus

NO-Patent Citations (4)

    CARMICHAEL J AND ALL.: "A phase II trial of ifosfamide/mesna with doxorubicin for malignant mesothelioma" EUROPEAN JOURNAL OF CANCER AND CLINICAL ONCOLOGY, vol. 25, no. 5, 1989, pages 911-912, XP008027688
    KAWAGUCHI AND ALL.: "Enhanced antitumor activity of cisplatin by combination with dimercapto compounds in a mouse model" JAPANESE JOURNAL OF PHARMACOLOGY, vol. 49, no. supp, 1989, page 72p XP008027903
    KLIEN H O AND ALL.: "Experimental and clinical investigations on the importance of sodium-2-mercapto-ethan-sulfonic acid (MAS) for the cytostatic treatment with oxazaphosphorines" NAUNYN-SCHMEIDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 313, no. supp, 1980, page r64 XP008027690
    See also references of WO 0048632A1

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