Novel redox clamping agents and uses thereof

Neuartige komplexierende redoxagenzien sowie deren verwendung

Nouveaux agents de fixation d'oxydoreduction et leurs utilisations

Abstract

Redox clamping agents which maintain cells in a selected redox state are provided. Also provided are methods of using the redox clamping agents to sensitize cells to chemotherapeutic agents such as antineoplastics, to inhibit hyperproliferation of cells and to stabilize the redox state of cells with abnormal fluctuations in their redox state.
L'invention concerne des agents de fixation d'oxydoréduction permettant de maintenir des cellules dans un état d'oxydoréduction donné. Cette invention concerne également des procédés d'utilisation de ces agents de fixation d'oxydoréduction destinés à sensibiliser les cellules à des agents chimiothérapeutiques comme les antinéoplasiques, de manière à inhiber l'hyperprolifération desdites cellules et à stabiliser l'état d'oxydoréduction des cellules dont l'état d'oxydoréduction fluctue de manière anormale.

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